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The aim of this study was to assess psychophysiological responding to emotional scripts.In 18 unmedicated patients with BPD and 18 healthy controls, startle responses were recorded while the subjects were first reading and then imagining standardized and personalized scripts with different emotional content.

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The results clearly show group differences in subjective and physiological responding to caffeine or caffeine-associated stimuli and will be discussed with reference to the anxiety-evoking effect of coffee in specific populations.

Research Network of Neuroscience at the University of Greifswald. Hamm2, & Arne Ohman1 1Karolinska Institutet, 2University of Greifswald Descriptors: fear conditioning, startle, genetics Fear conditioning and genetic accounts of anxiety disorder are typically seen as mutually excluding.

THE GENETICS OF FEAR LEARNING: FEAR CONDITIONED STARTLE POTENTIATION AND A POLYMORPHISM IN THE SEROTONIN TRANSPORTER GENE Tina B. However, a functional polymorphism in the serotonin transporter promoter region (5-HTTLPR) has been linked both to anxiety disorders and to amygdala reactivity.

Because fear potentiated startle is a validated measure of fear and reflects amygdala activity, we sought to reconcile these competing approaches to anxiety disorder by examining fear conditioning in participants genotyped for the 5-HTTLPR.

In addition, patients with BPD rated most of the scripts (including the pleasant ones) as more unpleasant and arousing.

On the other hand they reported less vividness of the pleasant images.Moreover, subsequently recognized emotional pictures induced larger heart rate deceleration compared to subsequently forgotten emotional pictures.In contrast, successfully encoded neutral pictures led to heart rate acceleration, whereas no heart rate changes were observed for subsequently forgotten neutral pictures.The assumption of emotional hyperreactivity of Linehan's theory could not be confirmed.Results will be discussed regarding possible moderating factors.Data analyses revealed a comparable affect modulation of startle responses for both groups.

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